Marcus Smith starts at fly-half and Owen Farrell returns at inside centre, while Manu Tuilagi moves to the wing when England face Australia on Saturday.
Smith came off the bench in the 69-3 thrashing of Tonga last weekend but will make his third Test start in place of George Furbank against the Wallabies at Twickenham.
Captain Farrell comes back into the team after missing the drubbing of the Pacific island nation due to his positive coronavirus test.
Tuilagi shifts from midfield to the right wing, with Jonny May on the other flank, and Maro Itoje will make his 50th appearance for his country in an unchanged pack.
Bevan Rodd and Raffi Quirke could make their debuts off the bench, but Joe Marler will not feature after the prop tested positive for COVID-19.
England head coach Eddie Jones said: “We know this will be a tough test for us, we’re playing against a team who have been together a while and who have beat the world champions twice. As an Australian, I know how much this game means.
“We’ve had a really good week of preparation, we’re looking to improve our performance this week and I think this side is building well.”
England: Freddie Steward, Manu Tuilagi, Henry Slade, Owen Farrell (captain), Jonny May, Marcus Smith, Ben Youngs; Ellis Genge, Jamie George, Kyle Sinckler, Maro Itoje, Jonny Hill, Courtney Lawes, Sam Underhill, Tom Curry.
Replacements: Jamie Blamire, Bevan Rodd, Will Stuart, Charlie Ewels, Alex Dombrandt, Sam Simmonds, Raffi Quirke, Max Malins.