Italy were drawn to face England and Germany in a tough 2022-23 Nations League group on Thursday.
The Azzurri beat England in the Euro 2020 final at Wembley in July and the two sides will do battle again in Group A3 of the Nations League.
They will also face Germany and Hungary home and away in matches that will take place next June and September 2022.
Holders France are in Group A1 along with Croatia, Denmark and Austria.
World champions France were crowned champions when they came from behind to beat Spain 2-1 at San Siro in October.
Spain were drawn in Group A2 and will come up against Portugal, Czech Republic and Switzerland in the third edition of the UEFA competition.
Belgium, who squandered a two-goal lead to lose against France at the semi-final stage of the Nations League two months ago, will take on Netherlands, Poland and Wales.
Scotland, Republic of Ireland, Ukraine and Armenia are in League B Group 1.
Russia, Iceland, Israel and Albania will do battle in Group B2, with Bosnia and Herzegovina, Finland and Romania in Group B3.
Group B4 will see Serbia, Sweden, Norway and Slovenia lock horns as they strive to secure promotion.
Four of the six matchdays will be in June due to the scheduling of the World Cup in Qatar later in 2022.
The four group winners in League A will advance to the Nations League Finals in June 2023. The group winners in the other three leagues will all be promoted for the 2024-25 edition.