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Courtney Lawes and Manu Tuilagi could make a welcome return for England in their Six Nations showdown with Wales at Twickenham.
Lawes may have been installed as England skipper for the tournament if he had not been sidelined due to concussion.
The towering lock missed the loss to Scotland and a win over Italy, but head coach Eddie Jones is hopeful he can face defending champions Wales a week on Saturday.
Centre Tuilagi could also be unleashed on Wayne Pivac’s side, having been back in action for Sale Sharks after recovering from a hamstring injury.
Lock Joe Launchbury (knee) and flanker Lewis Ludlam (ribs) could also be back in contention.
“Potentially we’ll have Launchbury, Tuilagi, Lawes and Ludlam,” Jones said.
Tom Curry has captained England in the absence of the injured Owen Farrell and Lawes.
But Lawes could have the honour of leading the Red Rose out once again in a battle between two sides who have won one and lost one of their matches heading into a weekend off.
The Australian added: “We’d be hopeful that by the end of next week Courtney will be training fully.
“He’s making some great progress and the medical staff have done some terrific work with him. He’s not far away now and we’re really hopeful he’ll be back in full training and able to play against Wales.”
Jones said of Tuilagi: “Just having a power running centre would give us a different option.
“Everything we’re doing now is about trying to create opportunities through finesse and that’s through good running lines and passing.
“But to have someone who can take you forward quickly and engage two or three defenders then allows you to try and finesse extra space, which would be really useful to us.
“We’ve had three centres play and I think Sladey [Henry Slade] has been very good. Joe Marchant and Elliot Daly have had their moments, but we need to get more out of that and we understand that.”
