Eddie Jones has selected uncapped full-back Tommy Freeman to play for England against the Barbarians, while Danny Care was named on the bench for the first time since 2018.
Care was due to play for the Barbarians at Twickenham on Sunday, having not been selected for England since being hooked at half-time against Japan four years ago.
The veteran Harlequins scrum-half has 84 England caps and has stood out in the Premiership this season, and now gets the chance to impress ahead of the three-Test tour of Australia in July.
England’s most capped player and regular scrum-half Ben Youngs is unavailable due to his commitments with Leicester Tigers in the Premiership final against Saracens on Saturday.
Care’s Harlequins team-mate Jack Walker also makes his first England appearance, with Freeman and Gloucester centre Mark Atkinson the other uncapped players to start.
Winger Joe Cokanasiga returns after an almost year-long absence, while Jonny May is on the other wing after a knee injury kept him out of the Six Nations.
Jonny Hill is another who missed the Six Nations but was recalled to the side, which will be captained by back-rower Tom Curry.
England’s Six Nations captain Courtney Lawes was named among the replacements, alongside the uncapped trio of Will Goodrick-Clarke, Patrick Schickerling and Orlando Bailey.
“This is a young team, they have prepared really well and worked hard over the past few camps to come together as a group,” Jones said.
“It is a great opportunity to play in this England XV side and show what they can do.
“We are looking forward to playing against an unusually French Barbarians side – which you normally only get when you play the French Barbarians.
“We’ll use it as an opportunity to develop combinations and assess players for the Australia tour.
“We will put our best foot forward and it should make for a great game of rugby for all of the supporters at Twickenham.”
England team: Tommy Freeman, Joe Cokanasiga, Joe Marchant, Mark Atkinson, Jonny May, Marcus Smith Harry Randall; Bevan Rodd, Will Collier, Charlie Ewels, Jonny Hill, Tom Curry, Sam Underhill, Alex Dombrandt.
Replacements: Jack Singleton, Will Goodrick-Clarke, Patrick Schickerling, Courtney Lawes, Jack Willis, Danny Care, Orlando Bailey, Jack Nowell.