Former Australian Open champion Sofia Kenin claimed her first victory since January at Tennis in the Land on Monday.
Kenin, who has struggled mightily with illness and injury since her triumph in Melbourne in 2020, has seen her ranking drop to 415 in the world.
She had lost her last nine matches but was back to winning ways in Cleveland, where Kenin earned a 6-4 6-3 win over qualifier Dalayna Hewitt in an all-American clash.
Bernarda Pera and Madison Brengle gave the home fans plenty to cheer about with first-round victories, while Lauren Davis came up short in three sets against third seed Ekaterina Alexandrova.
Seeds Martina Trevisan, Aliaksandra Sasnovich and Alize Cornet all sealed wins, the latter thrashing Dayana Yastremska for the loss of just three games.
At the Granby Championships, top seed Daria Kasatkina had to come from a set down to beat Greet Minnen 6-7 (4-7) 6-4 6-2 in just under three hours.
Seventh seed Kaja Juvan lost to 17-year-old Cadence Brace but seeds Jasmine Paolini, Anna Bondar, Nuria Parrizas Diaz, Tereza Martincova and Marta Kostyuk all emerged victorious.