Courtney Lawes will miss England’s pre-Autumn Nations Series training camp next week as he continues to work through his return to play protocols.
Lawes was initially named in a 36-man squad by Eddie Jones this week, but the lock will not travel to Jersey.
Captain of his country in the series win over Australia in July, Lawes has been suffering with concussion issues after taking a blow to the head during Northampton Saints’ derby defeat to Leicester Tigers last month.
The absence of Lawes will cast doubt on whether he will be fit for the Red Rose’s first November Test against Argentina at Twickenham on November 6.
London Irish’s Tom Pearson has been added to the squad and will join up for a five-day camp on Monday.
Head coach Jones would face a decision over who would lead his side if Lawes is unable to play, with Owen Farrell among the contenders to have the honour once again.
England will face Japan, New Zealand and world champions South Africa next month after taking on the Pumas.