Alex Coles will make his England Test debut on Saturday after being named in the team to face Argentina at Twickenham.
The 23-year-old will take his place in the second row against the Pumas after impressing at club level for the Saints.
Head coach Eddie Jones has made eight changes to the team that beat Australia in the third Test series-decider in July.
Owen Farrell will captain the side for the first of England’s Autumn Internationals in the absence of Courtney Lawes (concussion), with Manu Tuilagi next to him in midfield.
Joe Cokanasiga and Jack Nowell start on the wings, but there is no place for Jonny May despite suggestions he could return from his recent elbow injury.
Ben Young has been selected at scrum-half, with Jack van Poortvliet among the replacements.
The game against Michael Cheika’s men will be followed by further clashes at Twickenham against Japan, New Zealand and South Africa during November.
England team to face Argentina: 15. Freddie Steward, 14. Joe Cokanasiga, 13. Manu Tuilagi, 12. Owen Farrell (c), 11. Jack Nowell, 10. Marcus Smith, 9. Ben Youngs; 1. Ellis Genge, 2. Luke Cowan-Dickie, 3. Kyle Sinckler, 4. Alex Coles, 5. Jonny Hill, 6. Maro Itoje, 7. Tom Curry, 8. Billy Vunipola.
Replacements: 16. Jack Singleton, 17. Mako Vunipola, 18. Joe Heyes, 19. Dave Ribbans, 20. Sam Simmonds 21. Jack Willis, 22. Jack van Poortvliet, 23. Henry Slade.