Third seed Elise Mertens suffered a first-round exit at the Prague Open, while Caroline Garcia dispatched of Misaki Doi in the Poland Open.
Mertens, who reached the fourth round at Wimbledon at the start of July, succumbed to a 6-3 2-6 6-2 defeat to Magda Linette – her first loss to the Pole after three straight-set victories in their previous encounters.
The Belgian got just 52 per cent of her first serves in and won 38.5 per cent of points behind her second serve while only converting one of the five break points she earned.
Sixth seed Alison Van Uytvanck retired in the first set of her match against Dalila Jakupovic, while eighth seed Marie Bouzkova overcame Sinja Kraus 6-2 7-6 (7-2).
In Warsaw, fifth seed Garcia by no means had it easy in a 7-5 6-4 success over Doi.
The Frenchwoman committed eight double faults and only got 55 per cent of her first serves in, but by saving six of the eight break points she faced she was able to get the job done in straight sets.
Polish wildcard Maja Chwalinska was a 7-5 6-2 victor over qualifier Rebeka Masarova in only her second Tour-level tournament.