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Manchester City will seal a fifth Premier League title in six years if they beat Chelsea on the penultimate weekend of top-flight action.
Leeds and Leicester face must-win clashes in their fight to beat the drop against West Ham and Newcastle respectively.
Read on as we preview all 10 games with plenty to play for at the top and bottom of the table.
Tottenham vs Brentford (Saturday, 12.30pm, BT Sport)
Tottenham’s quest for European qualification continues with a tricky clash against Brentford in their final home game of a turbulent campaign.
Seventh-placed Spurs have lost 13 Premier League games this term, last losing more in a single season in 2008-09 (15).
Europe may just be out of reach for Thomas Frank’s Bees as they head to North London without talisman Ivan Toney following his eight-month ban for betting breaches.
They are unbeaten in eight games against London sides and are looking to record four consecutive league wins against fellow teams from the capital for the first time since March 2009, when they were in League Two.
Bournemouth vs Manchester United (Saturday, 3pm)
Manchester United have a one-point lead over Liverpool in the top-four race ahead of their trip to a Bournemouth side with safety already secured.
The Red Devils have won eight of their 11 Premier League clashes with Saturday’s opponents, though they did lose 1-0 on their last trip to the Vitality Stadium in November 2019.
Erik ten Hag’s men won the second-most points of any side away from home between August and December (16). But in 2023 they have just eight points from nine games on the road, the seventh lowest.
United have scored 11 league goals via substitutes this season, with 18-year-old Alejandro Garnacho responsible for the most with three, including last time out versus Wolves.
Fulham vs Crystal Palace (Saturday, 3pm)
Mid-table duo Fulham and Crystal Palace go head-to-head with their top-flight statuses firmly secured for another season.
Marco Silva’s hosts are looking to complete a Premier League double over their London counterparts for the first time but the visitors have won on their last two trips to Craven Cottage.
The Eagles have won five of their eight games under Roy Hodgson, just one success fewer than they had in the previous 28 matches.
Eberechi Eze is in scintillating form with six goals in his last seven appearances. His 10 goals overall have been worth a precious 11 points for the South Londoners.
Liverpool vs Aston Villa (Saturday, 3pm)
Jurgen Klopp will be absent from the touchline for Liverpool’s crucial clash with Aston Villa at Anfield as the Reds continue to battle for a place in the top four.
Klopp’s men face an opponent they have beaten in nine of the last 10 league meetings — with the exception being a 7-2 loss at Villa Park in October 2020.
Unai Emery’s Villa have European aspirations of their own, with only Manchester City, Arsenal and Saturday’s hosts picking up more points since the Spaniard’s appointment (45).
Mohamed Salah has scored in each of his last nine home games in all competitions, while Ollie Watkins has more goals against the Anfield club than any other opponent (five).
Wolves vs Everton (Saturday, 3pm)
A win for Everton at Wolves would go a long way to helping the Toffees avoid the drop.
Sean Dyche’s side sit a point above the relegation zone and can pile the pressure on Leeds and Leicester with victory on Saturday afternoon.
But Wolves have won their last three meetings with the Merseysiders, while they have also triumphed in two of the pair’s last three clashes at Molineux.
Dyche lost only once in the 11 times he faced Wolves during his time at Burnley (five wins, five draws), a 1-0 defeat in September 2018.
Nottingham Forest vs Arsenal (Saturday, 5.30pm, Sky Sports)
Arsenal know their Premier League title hopes are all but over as they face a difficult trip to Nottingham Forest.
Steve Cooper’s Reds still have work to do to secure safety but seven points from their last four games means survival is firmly in their hands.
The Gunners are looking to win five consecutive Premier League games against the Tricky Trees, while they have lost just two of their last 10 league trips to the City Ground (seven wins, one draw).
Seven of Forest’s eight league wins this season have come on their home patch but Mikel Arteta’s men have only failed to score in one of their 18 away clashes this term.
West Ham vs Leeds (Sunday, 1.30pm, Sky Sports)
Anything less than a win for Leeds at West Ham could spell the end of their three-year spell in the Premier League.
Sam Allardyce has lost one and drawn one since taking over the Whites as they sit a point adrift of safety with two games to go.
The Hammers, who sealed a place in the Europa Conference League final on Thursday, have won four of their last six meetings with their visitors from West Yorkshire.
Big Sam is winless in his last eight clashes with his former club, while he has also lost his last eight versus opposing manager David Moyes.
Brighton vs Southampton (Sunday, 2pm)
Brighton’s European hopes suffered a blow with a 4-1 defeat at Newcastle on Thursday night and they will now look to bounce back against relegated Southampton.
The Saints are unbeaten in their last six trips to the Amex (four wins, two draws), last losing on the Seagulls’ own patch in January 2012.
After their shock 5-1 defeat to Everton, Roberto De Zerbi’s men have now only won four of their 18 Premier League home games against sides in the relegation zone (10 draws, four defeats).
Only Glenn Murray (eight in 2018-19) has scored more home Premier League goals for Brighton in one campaign than Alexis Mac Allister has this term (seven).
Manchester City vs Chelsea (Sunday, 4pm, Sky Sports)
A third successive Premier League title beckons for Treble-chasing Man City as they welcome Chelsea to the Etihad.
Pep Guardiola’s men command a four-point lead over the Gunners and have three games left to play as they look to secure the crown ahead of their FA Cup and Champions League finals next month.
The pair face off for the fourth time this season, with the Citizens winning the three previous clashes. The only side to beat the Blues four times in one season was Manchester United in 2010-11.
Frank Lampard is one of only two managers to avoid defeat away at Manchester City this season, with his Everton side drawing 1-1 at the Etihad in December.
Newcastle vs Leicester (Monday, 8pm, Sky Sports)
Leicester could be relegated if they fail to beat Newcastle at St James’ Park.
The Toon’s top-four place looks to be all but secure after Thursday’s emphatic win as they look to complete their first league double over the Foxes since 1994-95.
Leicester have conceded 41 away league goals this season, their most in a campaign since shipping 44 on the road in 2010-11 in the Championship. In a 38-game season, it is the most since 1914-15.
Eddie Howe has never lost a home Premier League match against the Foxes (four wins, two draws), while all three of opposing boss Dean Smith’s top-flight trips to Newcastle have finished 1-1.
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