Sam Simmonds and Jack van Poortvliet will start for England against Japan at Twickenham on Sunday.
Eddie Jones has named five changes from the shock 30-29 defeat to Argentina last weekend as they prepare to face Japan, who he coached between 2012 and 2015.
Number eight Simmonds has not featured for England since the Six Nations in March but comes in for Billy Vunipola, who drops to the bench.
Alex Coles is replaced by debutant David Ribbans at lock while Van Poortvliet, who scored within 30 seconds of coming on the pitch against Argentina, will start at scrum-half.
Jonny May also comes in for Joe Cokanasiga and Guy Porter is the final introduction as he is chosen to start over Manu Tuilagi at outside centre.
Owen Farrell will captain England and earn his 99th international cap, while hooker Jamie George is on the bench after recovering from a foot injury.
England team to face Japan: 15. Freddie Steward, 14. Jack Nowell, 13. Guy Porter, 12. Owen Farrell (c), 11. Jonny May, 10. Marcus Smith, 9. Jack van Poortvliet; 1. Ellis Genge, 2. Luke Cowan-Dickie, 3. Kyle Sinckler, 4. David Ribbans, 5. Jonny Hill, 6. Maro Itoje, 7. Tom Curry, 8. Sam Simmonds.
Replacements: 16. Jamie George, 17. Mako Vunipola, 18. Joe Heyes, 19. Alex Coles, 20. Billy Vunipola, 21. Ben Youngs, 22. Henry Slade, 23. Manu Tuilagi.