England have lost Luke Cowan-Dickie for the remainder of the Six Nations due to a knee injury and Ireland prop Andrew Porter will also play no further part in the tournament.
Exeter Chiefs director of rugby Rob Baxter on Thursday confirmed Cowan-Dickie could be out for the rest of the season as he requires surgery.
The hooker did the damage in a 23-19 win over Wales at Twickenham last weekend and England forwards coach Richard Cockerill says his absence is a blow for the Red Rose in their quest to win the title.
Cockerill said: “We’re disappointed for him, for Exeter and obviously ourselves. He’s a really important player to the team and a leader to the group as well.
“So it’s a bit of a blow to the team, but we’ve got cover and that’s the game isn’t it, players get injured, you have to deal with that and someone else gets an opportunity.
“Jamie [George] is a fantastic player; he’s proven that for the last 10 years or so. He did a great job when he came on at the weekend and I’m sure he’s looking forward to doing that again.”
Ireland will have to do without Porter when they travel Twickenham to face Eddie Jones’ side a week on Saturday.
The prop sustained an ankle injury during the 57-6 round three rout of Italy, which left Ireland just a point behind leaders France in second place.
Ireland are hopeful centre Robbie Henshaw is passed fit to take on England after he suffered a head injury in the thrashing of the Azzurri.