Jordan Larmour has been ruled out of the remainder of Ireland’s Six Nations campaign after suffering a hip injury in Leinster’s win against Benetton on Saturday.
Larmour’s last appearance for his country came in the win against Japan in July 2021 at Lansdowne Road.
The 24-year-old back has made 30 test appearances for Ireland, with 13 starts, scoring seven tries.
Ireland had already lost prop Andrew Porter, who sustained an ankle injury during the 57-6 round three rout of Italy, which left Ireland just a point behind leaders France in second place.
Ireland are hopeful centre Robbie Henshaw will be passed fit to take on England after he suffered a head injury in the thrashing of the Azzurri.
Iain Henderson returns to the squad for Saturday’s game after missing the win over Italy with COVID-19, having played the full 80 minutes of Ulster’s victory against Cardiff on Friday.
Henderson missed the opening win over Wales because of an ankle injury and came off the bench in the loss to France in Paris.
Munster loosehead Jeremy Loughman has also been called up to the Irish squad for the first time as extra cover.